Collaboration en cours et publications


Université de Floride et Université de Utah (Etats Unis), Instituts Pasteur (Paris, Korée, Madagascar, Iran), IRD/MIVEGEC Montpellier, Université de Toulouse III, URMITE Marseille, et IBMC Strasbourg (France), NIPD Shanghai (Chine), NIMR Lagos (Nigeria), IMPM, Université de Yaoundé I, et Université de Douala (Cameroun).



Bracken F. Roberts, Yongsheng Zheng, Jacob Cleaveleand, Sukjun Lee, Eunyoung Lee, Lawrence Ayong, Yu Yuan, Debopam Chakrabarti. (2017). 4-Nitro styrylquinoline is an antimalarial inhibiting multiple stages of Plasmodium falciparum asexual life cycle International Journal for Parasitology: Drugs and Drug Resistance 2017, DOI 10.1016/j.ijpddr.2017.02.002 (in press)

Cecile Okalla Ebongue, Eveline Ngouadjeu Dongho, Gaetan Texier, Jean-Pierre Nda Mefo'o, Gerald Sume Etapelong, Lawrence Ayong, Carole Else Eboumbou Moukoko (2017). Residual risk of transfusion-transmitted malaria infection in a malaria endemic sub-Saharan African setting. Translational Medicine Communications, DOI 10.1186/s41231-017-0013-9 (in press)

Sandeu MM, Bayibéki AN, Tchioffo MT, Abate L, Gimonneau G, Awono-Ambéné PH, Nsango SE, Diallo D, Berry A, Texier G, Morlais I (2017). Do the venous blood samples replicate malaria parasite densities found in capillary blood? A field study performed in naturally-infected asymptomatic children in Cameroon. Malar J. 2017 Aug 17;16(1):345. doi: 10.1186/s12936-017-1978-6


Kemleu S, Guelig D, Eboumbou Moukoko C, Essangui E, Diesburg S, Mouliom A, Melingui B, Manga J, Donkeu C, Epote A, Texier G, LaBarre P, Burton R, Ayong L (2016). A Field-Tailored Reverse Transcription Loop-Mediated Isothermal Assay for High Sensitivity Detection of Plasmodium falciparum Infections. PLoS One. 2016 Nov 8;11(11):e0165506. doi:10.1371/journal.pone.0165506

Tarkang PA, Appiah-Opong R, Ofori MF, Ayong LS, Nyarko AK (2016). Application of multi-target phytotherapeutic concept in malaria drug discovery: a systems biology approach in biomarker identification. Biomark Res. 2016 Dec 13;4:25. doi: 10.1186/s40364-016-0077-0. eCollection 2016

D. Ménard, N. Khim, J. Beghain, A.A. Adegnika, M. Shafiul‑Alam, O. Amodu,G. Rahim‑Awab, C. Barnadas, A. Berry, Y. Boum, M.D. Bustos, J. Cao, J.-H. Chen,L. Collet, L. Cui, G.-D. Thakur, A. Dieye, D. Djallé, M.A. Dorkenoo,C.E. Eboumbou‑Moukoko, et al, for the KARMA Consortium (2016). A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms. N Engl J Med; 374: 25.

Wesley C. Van Voorhis, John H. Adams, Roberto Adelfio, Vida Ahyong, Myles H. Akabas, Pietro Alano, Aintzane Alday,Yesmalie Alemán Resto, AishahAlsibaee, Ainhoa Alzualde, Katherine T Andrews, Simon V. Avery, Vicky M Avery, Lawrence Ayong et al (2016). Open source drug discovery with the Malaria Box compound collection for neglected diseases and beyond, PLoS Pathog. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763. eCollection 2016 Jul.

Roberts, B.F., Iyamu, I.D., Lee, S., Lee, E., Ayong, L., Kyle, D.E., Yuan, Y., Manetsch, R., Chakrabarti, D. (2016). Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages, International Journal for Parasitology: Drugs and Drug Resistance 2016. Doi: 10.1016/j.ijpddr.2016.02.004.

Sandeu MM, Abate L, Tchioffo MT, Bayibéki AN, Awono-Ambéné PH, Nsango SE, Chesnais CB, Dinglasan RR, de Meeûs T, Morlais I (2016). Impact of exposure to mosquito transmission-blocking antibodies on Plasmodium falciparum population genetic structure. Infection, Genetics and Evolution 45: 138-144.

Imboumy-Limoukou RK, Maghendi-Nzondo S, Kouna CL, Bounaadja L, Mbang S, Biteghe JC, Eboumbou C, Prugnolle F, Florent I, Lekana-Douki JB. (2016). Immunoglobulin response to the low polymorphic Pf113 antigen in children from Lastoursville, South-East of Gabon. Acta Trop.; 163:149-56.

Mbida Mbida · J. Etang · P. AkonoNtonga · C. Eboumbou Moukoko · P. Awono-Ambene · D. Tagne A. Talipouo · W. Ekoko · J. Binyang · R. Tchoffo · G. Lehman · R. Mimpfoundi. (2016). New Insight into Anopheles coluzzii Coetzee & Wilkerson, 2013 larval ecology in the Wouriestuary, Littoral-Cameroon. Bull. Soc. Pathol; DOI 10.1007/s13149-016-0519-9. French article.

Mbida Mbida, J. Etang, P. AkonoNtonga, A. Talipouo, P. Awono-Ambene, F. Oke-Agbo, C. Eboumbou, M. Akogbéto, R. Osse, G. Lehman, W. Ekoko, J. Binyang, D. Tagne, R. Tchoffo, A. Dongmo and R. Mimpfoundi (2016). Preliminary investigation on aggressive culicidae fauna and malaria transmission in two wetlands of the Wouri river estuary, Littoral-Cameroon. Journal of Entomology and Zoology Studies; 4(6):105-110.

Etang J, MbidaMbida A, NtongaAkono P, Binyang J, Eboumbou Moukoko CE, Lehman LG, Awono-Ambene P, Talipouo A, EkokoEyisab W, Tagne D, Tchoffo R, Manga L, Mimpfoundi R (2016). Anopheles coluzzii larval habitat and insecticide resistance in the island area of Manoka, Cameroon. BMC Infect Dis; 16:217.

Tchioffo MT, Boissière A, Abate L, Nsango SE, Bayibéki AN, Awono-Ambéné PH, Christen R, Gimonneau G, Morlais I (2016). Dynamics of bacterial community composition in the malaria mosquito’s epithelia. Frontiers in Microbiology 6. doi: 10.3389/fmicb.2015.01500

Menard S, Tchoufack JN, Maffo CN, Nsango SE, Iriart X, Abate L, Tsapi MT, Awono-Ambéné PH, Abega Mekongo FA, Morlais I, Berry A (2016). Insight into k13-propeller gene polymorphism and ex vivo DHA-response profiles from Cameroonian isolates. Malaria Journal 15: 572. doi: 10.1186/s12936-016-1622-x


Eboumbou Moukoko EC, Ngo Sack F, Essangui Same GE Mbangue M, Lehman GL (2014). HIV, HBV, HCV and T. pallidum infections among blood donors and Transfusion-related complications among recipients at the Laquintinie hospital in Douala, Cameroon. BMC Hematology ; 14:5.

Morlais I, Nsango SE, Toussile W, Abate L, Annan Z, Tchioffo MT, Cohuet A, Awono-Ambene PH, Fontenille D, Rousset F, Berry A (2015). Plasmodium falciparum Mating Patterns and Mosquito Infectivity of Natural Isolates of Gametocytes. Plos One 10: e0123777

Chauvin P, Menard S, Iriart X, Nsango SE, Tchioffo MT, Abate L, Awono-Ambéné PH, Morlais I, Berry A (2015). Prevalence of Plasmodium falciparum parasites resistant to

sulfadoxine/pyrimethamine in pregnant women in Yaoundé, Cameroon: emergence of highly resistant pfdhfr/pfdhps alleles. Journal of Antimicrobial Chemotherapy. doi: 10.1093/jac/dkv160

Nnanga Nga, Eboumbou Moukoko EC, Ngene JP, Ewoudou MER, MpondoMpondo E (2015). Pharmacotechnical evaluation of Artemether and Lumefantrine 20/120 tablet of legal and illegal markets in Yaoundé. Health Sci. Dis; 16(2).French article.


Sukjun Lee, Donghyun Lim, Eunyoung Lee, Nakyung Lee, Hong-gun Lee, Jonathan Cechetto, Michel Liuzzi, Lucio Freitas-Junior, Sangmi Oh, Seung Bum Park and Lawrence Ayong (2014). Discovery of carbohybrid-based 2-aminopyrimidine analogues as a new class of rapid-acting antimalarial agents using a novel image-based cytological profiling assay. J Med Chem 2014 Sept 11; 57(17):7425-34

Tarkang PA, Okalebo FA, Ayong LS, Agbor GA, Guantai AN (2014). Anti-malarial activity of a polyherbal product (Nefang) during early and established Plasmodium infection in rodent models. Malar J. 2014 Nov 25; 13:456.

Tarkang PA, Franzoi KD, Lee S, Lee E, Vivarelli D, Freitas-Junior L, Luizzi M, Nole T, Ayong LS, Agbor GA, Okalebo F, Guantai A (2014). In vitro antiplasmodial activities and synergistic combinations of differential solvent extracts of the polyherbal product, Nefang. Hindawi Biomed Research International.2014 April 04


Boissière A, Gimonneau G, Tchioffo MT, Abate L, Bayibeki A, Awono Ambéné PH, Nsango SE, Morlais I (2013). Application of a qPCR Assay in the Investigation of Susceptibility to Malaria Infection of the M and S Molecular Forms of An. gambiae s.s. in Cameroon. PLoS ONE 8:e54820. doi: 10.1371/journal.pone.0054820

Laura M Alcantara, Junwon Kim, Carolina B Moraes, Caio H Franco, Kathrin D Franzoi, Sukjun Lee, Lucio H Freitas-Junior, LS. Ayong (2013). Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites. Exp Parasitol. 2013 Jun;134(2):235-43. doi: 10.1016/j.exppara.2013.03.022. Epub 2013 Mar 28.

Ngo Sack Françoise, C. Eboumbou Moukoko, E. Ngouadjeu, H. Zouhaïratou, D. Mbanya(2013). Prevalence of HIV among sickle cell disease patients followed at the Yaoundé Central Hospital. Health Sciences and Disease; 14 : 2.

Nsango SE, Pompon J, Xie T, Rademacher A, Fraiture M, Thoma M, Awono-Ambene PH, Moyou RS, Morlais I, Levashina EA (2013). AP-1/Fos-TGase2 Axis Mediates Wounding-induced Plasmodium falciparum Killing in Anopheles gambiae. Journal of Biological Chemistry 288: 16145-16154.

Seunghyun Moon, Sukjun Lee, Heechang Kim, Lucio H. Freitas-Junior, Myungjoo Kang, Lawrence Ayong, Michael A. E. Hansen (2013). iMAL: An analysis algorithm for malaria parasite stage classification and viability quantification. PLoS One. 2013 Apr 23;8(4):e61812. doi: 10.1371/journal.pone.0061812. Print 2013

Tchioffo MT Tchioffo MT, Boissière A, Churcher TS, Abate L, Gimonneau G, Nsango SE, Awono-Ambéné PH, Christen R, Berry A, Morlais I (2013). Modulation of malaria infection in Anopheles gambiae mosquitoes exposed to natural midgut bacteria. PLoS One. 2013 Dec 6;8(12): e81663.

Yonghui Zhang, Wei Zhu, Yi-Liang Liu, Hong Wang, Ke Wang, Kai Li, Joo Hwan No, Lawrence Ayong, Anmol Gulati, Ran Pang, Lucio Freitas-Junior, Craig T. Morita, and Eric Oldfield (2013). Chemo-immunotherapeutic antimalarials targeting isoprenoid biosynthesis. ACS Med Chem Lett. 2013 Apr 11;4(4):423-427.

2012 :

Nsango SE, Abate L, Thoma M, Pompon J, Fraiture M, Rademacher A, Berry A, Awono-Ambene PH, Levashina EA, Morlais I, (2012). Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae. International Journal for Parasitology 42: 589-595.

Boissière A, Tchioffo MT, Bachar D, Abate L, Marie A, Nsango SE, Shahbazkia HR, Awono-Ambene PH, Levashina EA, Christen R, Morlais I (2012). Midgut Microbiota of the Malaria Mosquito Vector Anopheles gambiae and Interactions with Plasmodium falciparum Infection. Plos Pathog 8: e1002742 doi: 10.1371/journal.ppat.1002742

Caroline Harris, Louis Lambrechts, François Rousset, Luc Abate, Sandrine E. Nsango, Didier Fontenille, Isabelle Morlais, Anna Cohuet (2010). Polymorphisms in Anopheles gambiae Immune Genes Associated with Natural Resistance to Plasmodium falciparum. PLoS Pathog. 6(9): e1001112.

Christian Mitri, Jean-Claude Jacques, Isabelle Thiery, Michelle M. Riehle, Jiannong Xu, Emmanuel Bischoff, Isabelle Morlais, Sandrine E. Nsango, Kenneth D. Vernick, Catherine Bourgouin. Fine Pathogen Discrimination within the APL1 Gene Family Protects Anopheles gambiae against Human and Rodent Malaria Species. PLoS Pathog. 2009 Sep;5(9):e1000576. doi: 10.1371/journal.ppat.1000576

Min-Je K, Dossin F, Hansen M, Genovesio A, Ayong L, Freitas-junior L (2012). An image-based drug susceptibility assay targeting the placental sequestration of Plasmodium falciparum-infected erythrocytes. PLoS One. 2012; 7(8): e41765. Epub 2012 Aug 29


2011 :

Ayong L, Mauser J, DaSilvia T, Allen C, Chakrabarti D (2011). Evidence for prenylation-dependent trafficking of a Ykt6 SNARE in Plasmodium falciparum. Mol Biochem Parasitol. 175(2): 162-8

Mendes AM, Awono-Ambene PH, Nsango SE, Cohuet A, Fontenille D, Kafatos FC, Christophides GK, Morlais I, Vlachou D (2011). Infection Intensity-Dependent Responses of Anopheles gambiae to the African Malaria Parasite Plasmodium falciparum. Infection and Immunity 79: 4708-4715. doi: 10.1128/iai.05647-11

Moreno SN, Ayong L, Pace DA (2011). Calcium storage and function in apicomplexan parasites. Essays Biochem, 51:97-110

Rooney PJ, Ayong L, Tobin CM, Moreno SN, Knoll LJ (2011). TgVTC2 is involved in polyphosphate accumulation in Toxoplasma gondii. Mol Biochem Parasitol. 176(2): 121-6



Aubouy A., Kheliouen N, Tuikue-Ndam N, Viwami F, Lalya F, Eboumbou Moukoko EC, Rogier C, Deloron P (2010). Variant surface antigens in cerebral malaria: distinct from others and similar to each other? Malaria Journal, 9(Suppl 2):O2

Halbert J, Ayong L, Equinet L, Le Roch K, Hardy M, Goldring D, Reininger L, Walters N, Chakrabarti D, Doerig C (2010). A Plasmodium falciparum transcriptional cyclin-dependent kinase-related kinase with a crucial role in parasite proliferation associates with histone deacetylase activity. Eukaryotic Cell, 9(6): 952-9

Kheliouen N, Viwami F, Lalya F, Tuikue-Ndam N, Eboumbou Moukoko EC, Rogier C, Deloron P, Aubouy A. (2010). Plasmodium falciparum parasites causing cerebral malaria share variant surface antigens, but are they specific? Malaria Journal; 9(1): 220-227